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Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional)

Open

National Institutes of Health

Deadline: Jan 7, 2028federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to support invasive neural recording studies that investigate mental health-related questions, aiming to fill gaps in understanding neural circuit functions associated with mental health disorders. Eligible applicants include a wide range of entities such as private and public higher education institutions, nonprofits, for-profit organizations, government entities, and various community organizations. To apply, interested parties should refer to the full opportunity announcement for detailed application instructions.

Full Description

Reissue of RFA-20-351.The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications to pursue invasive neural recording studies focused on mental health-relevant questions. Invasive neural recordings provide an unparalleled window into the human brain to explore the neural circuitry and neural dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high spatial and temporal resolution. Additionally, the ability to stimulate, via the same electrodes, allows for direct causal tests by modulating network dynamics. This funding opportunity aims to...

Eligibility

Eligible applicants

Education

  • Private institutions of higher education
  • Public and state institutions of higher education
  • Independent school districts

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)

Business

  • For-profit organizations other than small businesses
  • Small businesses

Government

  • Public and Indian housing authorities
  • City or township governments
  • County governments
  • State governments
  • Special district governments
  • Federally recognized Native American tribal governments

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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