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Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01 Clinical Trial Optional)

Open

National Institutes of Health

Deadline: Jan 7, 2028federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to support invasive neural recording studies that investigate mental health-related questions, aiming to enhance understanding of neural circuitry and dynamics associated with mood, emotions, and behaviors. Eligible applicants include various government entities, educational institutions, small and for-profit businesses, nonprofits, and other organizations, including those serving specific communities such as Native American tribes and historically underrepresented groups. Application details are not specified in the provided text; interested parties should refer to the full opportunity announcement for more information.

Full Description

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications to pursue invasive neural recording studies focused on mental health-relevant questions. Invasive neural recordings provide an unparalleled window into the human brain to explore the neural circuitry and neural dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high spatial and temporal resolution. Additionally, the ability to stimulate, via the same electrodes, allows for direct causal tests by modulating network dynamics. This funding opportunity aims to target a gap in the scientific...

Eligibility

Eligible applicants

Government

  • Special district governments
  • Public and Indian housing authorities
  • State governments
  • City or township governments
  • Federally recognized Native American tribal governments
  • County governments

Education

  • Independent school districts
  • Private institutions of higher education
  • Public and state institutions of higher education

Business

  • Small businesses
  • For-profit organizations other than small businesses

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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