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Towards a Better Understanding of the Neurological Effects of Infection-Associated Chronic Illnesses (R21 - Clinical Trial Optional)

Closed

National Institutes of Health

Deadline: Nov 16, 2025federal

Updated: Oct 30, 2025

Summary

The grant aims to support research on neurological and mental health issues related to infection-associated chronic illnesses, including conditions like Neuro-PASC and ME/CFS, with a focus on understanding common mechanisms and developing effective treatments. Eligible applicants include for-profit organizations, small businesses, educational institutions, government entities, nonprofits, and various other organizations, including those serving specific communities. Application details are not specified in the provided text; interested parties should refer to the full opportunity announcement for more information.

Full Description

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications focused on the neurological and/or mental health-related manifestations of infection-associated chronic illnesses, including the post-acute sequelae of COVID-19 (Neuro-PASC) as well as other chronic illnesses with a potential infectious trigger (post-treatment Lyme Disease, myalgic encephalomyelitis/chronic fatigue syndrome [ME/CFS], postural orthostatic tachycardia syndrome [POTS], post-viral fatigue syndromes, etc.). Projects that investigate common neurological and/or mental health-related mechanisms across multiple...

Eligibility

Eligible applicants

Miscellaneous

  • Other

Business

  • For-profit organizations other than small businesses
  • Small businesses

Education

  • Private institutions of higher education
  • Independent school districts
  • Public and state institutions of higher education

Government

  • Special district governments
  • State governments
  • Public and Indian housing authorities
  • Federally recognized Native American tribal governments
  • City or township governments
  • County governments

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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