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Technology Development Research for Establishing Feasibility and Proof of Concept (R21 - Clinical Trial Not Allowed)

Open

National Institutes of Health

Deadline: Jan 7, 2028federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to support exploratory research that leads to proof of concept for new technologies aligned with the NIGMS mission, focusing on high-risk and novel projects with significant potential impact in biomedical research. Eligible applicants include various nonprofit organizations, for-profit businesses (including small businesses), government entities, educational institutions, and specific minority-serving institutions, while non-domestic entities are not eligible to apply. Application details are not specified in the provided description; however, interested parties can contact NIH Grants Information for further inquiries.

Full Description

Description

This Notice of Funding Opportunity (NOFO)supports exploratory research leading to proof of concept for the development of new technologies relevant to the NIGMS mission. Projects should entail a high degree of risk and/or novelty, and have a high future potential impact in biomedical research.

Eligibility

Eligible applicants

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)

Business

  • For-profit organizations other than small businesses
  • Small businesses

Government

  • State governments
  • County governments
  • Special district governments
  • Public and Indian housing authorities
  • City or township governments
  • Federally recognized Native American tribal governments

Miscellaneous

  • Other

Education

  • Independent school districts
  • Public and state institutions of higher education
  • Private institutions of higher education

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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