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Targeting Cell Surface HIV Envelope for Cell Elimination (R01 Clinical Trial Not Allowed)

Open

National Institutes of Health

Deadline: Jan 7, 2028federal

Updated: Oct 30, 2025

Summary

The grant aims to support research on HIV-1 Envelope cell surface expression, mechanisms of biologic-mediated cell killing, and the development of innovative strategies to enhance the targeting of HIV-1 infected cells, ultimately contributing to immunotherapy and vaccine development for HIV-1. Eligible applicants include various government entities, nonprofits, educational institutions, businesses, and other organizations, including specific minority-serving institutions. Application details are not provided in the description; interested parties should refer to the full opportunity announcement for further instructions.

Full Description

Description

The purpose of this notice of funding opportunity (NOFO) is to support the investigation of HIV-1 Envelope (Env) cell surface expression, the structural mechanism of biologic-mediated cell killing, and the development of novel approaches to enhance the recognition and elimination of Env-expressing, HIV-1 infected cells. These studies are expected to inform the development of immunotherapies and targeted vaccines for HIV-1 prevention and cure.

Eligibility

Eligible applicants

Government

  • County governments
  • State governments
  • Federally recognized Native American tribal governments
  • Public and Indian housing authorities
  • City or township governments
  • Special district governments

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations

Education

  • Private institutions of higher education
  • Public and state institutions of higher education
  • Independent school districts

Miscellaneous

  • Other

Business

  • For-profit organizations other than small businesses
  • Small businesses

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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