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Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants (R01 Clinical Trial Not Allowed)

Open

National Institutes of Health

Deadline: Oct 14, 2026federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to accelerate the translation of NCI-supported assays to clinical settings, focusing on the adaptation and clinical validation of biomarkers for cancer detection, diagnosis, and treatment response. Eligible applicants include government entities, nonprofits, businesses, educational institutions, and various organizations, including those serving Native American populations and historically underrepresented groups. To apply, interested parties should refer to the full opportunity announcement for specific application instructions and additional details.

Full Description

Description

Through this Notice of Funding Opportunity (NOFO) is to accelerate the pace of translation of NCI-supported methods/assays/technologies (referred to as "assays") to the clinic. Specifically, the focus of this NOFO is on the adaption and clinical validation of molecular/cellular/imaging markers (referred to as "markers" r "biomarkers") for cancer detection, diagnosis, prognosis, monitoring, and prediction of response in treatment, as well as markers for cancer control and prevention. Research applications may support the acquisition of well-annotated specimens from NCI-supported or other clinical...

Eligibility

Eligible applicants

Government

  • City or township governments
  • Public and Indian housing authorities
  • State governments
  • Federally recognized Native American tribal governments
  • Special district governments
  • County governments

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)

Business

  • Small businesses
  • For-profit organizations other than small businesses

Education

  • Public and state institutions of higher education
  • Private institutions of higher education
  • Independent school districts

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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