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Pilot Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 Clinical Trial Required)

Open

National Institutes of Health

Deadline: Oct 15, 2027federal

Updated: Oct 30, 2025

Summary

The grant aims to support pilot effectiveness studies for optimizing preventive and therapeutic interventions and developing innovative services interventions in mental health. Eligible applicants include various government entities, educational institutions, for-profit and nonprofit organizations, and other specific groups such as tribal organizations and HBCUs. Application details are not provided in the description, but interested parties can contact NIH Grants Information for further inquiries.

Full Description

Pilot Effectiveness Trials for Treatment, Preventive and Services Interventions (R01 Clinical Trial Required). As part of NIMH's clinical trials pipeline NOFOs, this announcement encourages pilot effectiveness studies focused on 1) optimizing the effectiveness of preventive and therapeutic interventions with previously demonstrated efficacy, for use with broader target populations or for use in community practice settings, and 2) developing and preliminary testing innovative services interventions. Consistent with the NIMH experimental therapeutics approach, this NOFO is intended to support pilot...

Eligibility

Eligible applicants

Government

  • County governments
  • City or township governments
  • Special district governments
  • Federally recognized Native American tribal governments
  • State governments
  • Public and Indian housing authorities

Miscellaneous

  • Other

Education

  • Private institutions of higher education
  • Independent school districts
  • Public and state institutions of higher education

Business

  • For-profit organizations other than small businesses
  • Small businesses

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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