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Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)

Open

National Institutes of Health

Deadline: May 7, 2027federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to support pilot and preliminary research aimed at preparing for larger-scale effectiveness trials related to drug, tobacco, or alcohol use disorder treatments and services for comorbid conditions. Eligible applicants include various government entities, nonprofits, educational institutions, small businesses, and other organizations, including those serving specific communities such as Native American tribes and historically black colleges. To apply, interested parties should refer to the full opportunity announcement for detailed application instructions and contact NIH Grants Information for further inquiries.

Full Description

Description

This Notice of Funding Opportunity (NOFO) encourages pilot and preliminary research in preparation for larger-scale services research effectiveness trials. Relevant trials may test a wide range of approaches, including interventions, practices, and policies designed to optimize access to, and the quality, effectiveness, affordability and utilization of drug, tobacco, or alcohol use disorder treatments and related services, as well as services for comorbid medical and mental disorder conditions. Relevant approaches may include both those that are novel, and those that are commonly used in practice...

Eligibility

Eligible applicants

Government

  • Public and Indian housing authorities
  • State governments
  • Special district governments
  • City or township governments
  • County governments
  • Federally recognized Native American tribal governments

Miscellaneous

  • Other

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations

Education

  • Private institutions of higher education
  • Independent school districts
  • Public and state institutions of higher education

Business

  • Small businesses
  • For-profit organizations other than small businesses

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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