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NIH Research Project Grant (Parent R01 Clinical Trial Required)

Open

National Institutes of Health

Deadline: Jan 7, 2028federal

Updated: Oct 30, 2025

Summary

The NIH Research Project Grant aims to support specific research projects that include at least one clinical trial, aligned with the interests of participating NIH Institutes and Centers. Eligible applicants include various government entities, educational institutions, nonprofits, and for-profit organizations, including small businesses. To apply, interested parties should refer to the full opportunity announcement for detailed application instructions.

Full Description

The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Notice of Funding Opportunity Announcement requires that at lease 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

Eligibility

Eligible applicants

Government

  • State governments
  • Public and Indian housing authorities
  • City or township governments
  • Special district governments
  • County governments
  • Federally recognized Native American tribal governments

Education

  • Independent school districts
  • Public and state institutions of higher education
  • Private institutions of higher education

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)

Miscellaneous

  • Other

Business

  • For-profit organizations other than small businesses
  • Small businesses

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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