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NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)

Open

National Institutes of Health

Deadline: Jan 7, 2028federal

Updated: Oct 30, 2025

Summary

The NIH Research Project Grant aims to support discrete, specified projects in basic science experimental studies involving human participants, focusing on understanding fundamental phenomena without specific applications in mind. Eligible applicants include various government entities, nonprofits, educational institutions, small businesses, and other organizations, including those serving Native American populations and historically underrepresented groups. To apply, interested parties should refer to the full opportunity announcement for detailed instructions and contact NIH Grants Information for further inquiries.

Full Description

Description

The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Notice of Funding Opportunity is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this NOFO include studies that prospectively assign human participants to conditions...

Eligibility

Eligible applicants

Government

  • Public and Indian housing authorities
  • Federally recognized Native American tribal governments
  • State governments
  • County governments
  • City or township governments
  • Special district governments

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations

Education

  • Private institutions of higher education
  • Public and state institutions of higher education
  • Independent school districts

Business

  • Small businesses
  • For-profit organizations other than small businesses

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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