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NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)

Open

National Institutes of Health

Deadline: Jan 7, 2028federal

Updated: Oct 30, 2025

Summary

The NIH Exploratory/Developmental Grant aims to support early-stage research projects that may involve significant risk but have the potential for breakthroughs in biomedical, behavioral, or clinical research, requiring at least one proposed clinical trial. Eligible applicants include various nonprofit organizations, government entities, educational institutions, small businesses, and other specified groups, including Native American tribal organizations and historically black colleges. Application details are not explicitly provided in the description; interested parties should refer to the full opportunity announcement for further instructions.

Full Description

Description

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Notice of Funding Opportunity requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic...

Eligibility

Eligible applicants

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations

Government

  • State governments
  • Special district governments
  • Public and Indian housing authorities
  • City or township governments
  • Federally recognized Native American tribal governments
  • County governments

Education

  • Independent school districts
  • Private institutions of higher education
  • Public and state institutions of higher education

Business

  • Small businesses
  • For-profit organizations other than small businesses

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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