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NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)

Open

National Institutes of Health

Deadline: Jan 7, 2028federal

Updated: Oct 30, 2025

Summary

The NIH Exploratory/Developmental Grant aims to support early-stage research projects that may involve significant risk but have the potential to lead to breakthroughs in biomedical, behavioral, or clinical research. Eligible applicants include various nonprofit organizations, government entities, educational institutions, for-profit organizations, and other specified groups such as tribal organizations and historically black colleges. To apply, interested parties should refer to the full opportunity announcement for detailed application instructions and additional contact information.

Full Description

Description

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

Eligibility

Eligible applicants

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)
  • Nonprofits non-higher education without 501(c)(3)

Government

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Public and Indian housing authorities
  • Federally recognized Native American tribal governments

Education

  • Public and state institutions of higher education
  • Independent school districts
  • Private institutions of higher education

Business

  • For-profit organizations other than small businesses
  • Small businesses

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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