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National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional)

Open

National Institutes of Health

Deadline: Oct 25, 2027federal

Updated: Oct 30, 2025

Summary

The grant aims to advance the discovery and development of new treatments for mental disorders, substance use disorders, and alcohol use disorder, encouraging partnerships between academia and industry. Eligible applicants include public and private higher education institutions, nonprofits, government entities, and for-profit organizations, among others. Application details are not specified in the provided text, but interested parties should refer to the full opportunity announcement for more information.

Full Description

Reissue of PAR-20-118. This Notice of Funding Opportunity (NOFO) encourages applications to advance the discovery, preclinical development, and proof of concept (PoC) testing of new, rationally based candidate agents and neurostimulation approaches to treat mental disorders, substance use disorders (SUDs) or alcohol use disorder (AUD), and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets. Partnerships between academia and industry are strongly encouraged. This NOFO using the U01 mechanism supports a discrete,...

Eligibility

Eligible applicants

Education

  • Public and state institutions of higher education
  • Independent school districts
  • Private institutions of higher education

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)

Government

  • City or township governments
  • Special district governments
  • Federally recognized Native American tribal governments
  • County governments
  • Public and Indian housing authorities
  • State governments

Miscellaneous

  • Other

Business

  • For-profit organizations other than small businesses
  • Small businesses

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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