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Mitochondrial-associated Mechanisms of Neuropathological and Immunodeficient Aging in the Context of HIV and SUD (R21 Clinical Trials Not Allowed)

Open

National Institutes of Health

Deadline: Mar 10, 2026federal

Updated: Oct 30, 2025

Summary

The grant aims to support research on the protective and pathogenic mechanisms related to mitochondrial function and aging in the context of HIV infection and substance use, with the goal of developing targeted therapies for affected individuals. Eligible applicants include small businesses, various educational institutions, government entities, nonprofits, and other organizations, including those serving specific communities and populations. Application details are not provided in the description; for further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.

Full Description

Description

To promote research investigating protective and pathogenic mechanisms at the nexus of mitochondria function and aging in the context of HIV infection and exposure to addictive substances. We anticipate this foundational knowledge could be leveraged to develop targeted therapies and improve outcomes in people aging with HIV, substance use and addiction.

Eligibility

Eligible applicants

Business

  • Small businesses
  • For-profit organizations other than small businesses

Education

  • Public and state institutions of higher education
  • Private institutions of higher education
  • Independent school districts

Government

  • Special district governments
  • State governments
  • Public and Indian housing authorities
  • City or township governments
  • County governments
  • Federally recognized Native American tribal governments

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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