The National Institute of Mental Health intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research to identify modifiable targets and mechanisms to alleviate clinically relevant central nervous system (CNS) complications in people with HIV. This NOFO supports research that leverages patient derived data and innovative model platforms to identify and validate novel therapeutic targets underlying CNS complications. Building on advances in systems biology, this initiative seeks to identify modifiable mechanisms contributing to CNS dysfunction through clinical studies or pre-clinical model systems. The ultimate goal is to accelerate the development of effective, mechanism-based interventions that address the multifactorial and heterogeneous nature of CNS complications. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise in systems biology, pre-clinical models, clinical trial methodologies and translational neurobiology should consider applying to this NOFO. 

Education

• Private institutions of higher education
• Public and state institutions of higher education
• Independent school districts

Government

• Federally recognized Native American tribal governments
• Public and Indian housing authorities
• State governments
• County governments

Business

• Small businesses
• For-profit organizations other than small businesses

Nonprofit

• Nonprofits non-higher education with 501(c)(3)
• Other Native American tribal organizations