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Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R21 Clinical Trial Not Allowed)

Open

National Institutes of Health

Deadline: Jan 7, 2027federal

Updated: Oct 30, 2025

Summary

The grant aims to fund preclinical and patient-based studies that explore how incretin mimetics affect cancer risk, encouraging researchers to investigate the long-term implications of these agents rather than just short-term outcomes. Eligible applicants include various nonprofit organizations, government entities, small and for-profit businesses, educational institutions, and other specified groups such as Native American tribal organizations and historically black colleges. Application details are not provided in the description; interested parties should refer to the full opportunity announcement for further information.

Full Description

The goal of the proposed funding announcement is twofold, to promote preclinical and patient based studies examining the mechanism(s) through which incretin mimetics (including agonists or antagonists of GLP-1, GIP-1, or dual GLP-1/GIP-1 agents) impact cancer risk, and to draw talented scientists who understand the dynamic changes caused by these agents to investigate the mechanisms of how these agents influence cancer risk rather than shorter term outcomes such as weight loss and diabetes. The data thus far suggests that these agents may increase the risk of some, while decreasing the risk of other obesity related cancers.

Eligibility

Eligible applicants

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations

Government

  • County governments
  • State governments
  • Public and Indian housing authorities
  • City or township governments
  • Special district governments
  • Federally recognized Native American tribal governments

Business

  • Small businesses
  • For-profit organizations other than small businesses

Education

  • Independent school districts
  • Public and state institutions of higher education
  • Private institutions of higher education

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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