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Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R21 - Clinical Trial Optional)

Open

National Institutes of Health

Deadline: Nov 16, 2027federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to support research aimed at developing new screening methods and therapeutic interventions for serious conditions identified through newborn screening, particularly for "high priority" genetic conditions that could benefit from early detection and treatment. Eligible applicants include state and local governments, nonprofits, educational institutions, small businesses, and various other organizations, including those serving specific communities. To apply, interested parties should refer to the full opportunity announcement for detailed application instructions.

Full Description

This FOA encourages research relevant to the development of novel screening approaches and/or therapeutic interventions for potentially fatal or disabling conditions that have been identified through newborn screening, as well as for "high priority" genetic conditions where screening may be possible in the near future.Having an accurate screening test, as well as demonstrating the benefits of early intervention or treatment, are important criteria for including a condition on a newborn screening panel. This FOA defines a "high priority" condition as one where screening is not currently recommended, but infants with the condition would significantly benefit from early identification and treatment.

Eligibility

Eligible applicants

Government

  • State governments
  • County governments
  • Federally recognized Native American tribal governments
  • Special district governments
  • Public and Indian housing authorities
  • City or township governments

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)

Education

  • Public and state institutions of higher education
  • Independent school districts
  • Private institutions of higher education

Business

  • Small businesses
  • For-profit organizations other than small businesses

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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