INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)
OpenUpdated: Oct 30, 2025
Summary
The NIH INCLUDE Project aims to enhance health and quality of life for individuals with Down syndrome by funding Transformative Research Award applications that propose innovative and unconventional research with significant potential impact. Eligible applicants include various nonprofit organizations, educational institutions, government entities, and businesses, including small and for-profit organizations. To apply, interested parties should submit their proposals without the need for preliminary data, demonstrating a strong logic for potential major impacts in Down syndrome research.
Full Description
Description
The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.
Eligibility
Eligible applicants
Nonprofit
- Nonprofits non-higher education without 501(c)(3)
- Other Native American tribal organizations
- Nonprofits non-higher education with 501(c)(3)
Education
- Public and state institutions of higher education
- Independent school districts
- Private institutions of higher education
Government
- Special district governments
- Federally recognized Native American tribal governments
- State governments
- City or township governments
- County governments
- Public and Indian housing authorities
Miscellaneous
- Other
Business
- Small businesses
- For-profit organizations other than small businesses
Additional information
Grantor contact information
Description
schrammc@nih.gov
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