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In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed)

Open

National Institutes of Health

Deadline: Jan 7, 2026federal

Updated: Oct 30, 2025

Summary

The grant aims to support research on embryonic lethal knockout mouse strains generated by the International Mouse Phenotyping Consortium (IMPC) to enhance the understanding of mammalian gene function and its implications for human genetic variation. Eligible applicants include a wide range of institutions such as public and private higher education institutions, government entities, nonprofits, and small businesses. Application details are not specified in the provided text, but interested parties can contact NIH Grants Information for further inquiries.

Full Description

Description

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to phenotype and/or perform research on embryonic lethal knockout (KO) mouse strains being generated through the International Mouse Phenotyping Consortium (IMPC) of which the NIH Knockout Mouse Phenotyping Program (KOMP2) is a member. The mission of IMPC is to generate a comprehensive catalogue of mammalian gene function that will provide the foundation for functional analyses of human genetic variation. The current (July 19, 2022) IMPC data release includes phenotypic data for 8260 knockout genes. Overall,...

Eligibility

Eligible applicants

Education

  • Private institutions of higher education
  • Public and state institutions of higher education
  • Independent school districts

Government

  • Special district governments
  • Public and Indian housing authorities
  • County governments
  • City or township governments
  • Federally recognized Native American tribal governments
  • State governments

Miscellaneous

  • Other

Business

  • Small businesses
  • For-profit organizations other than small businesses

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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