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Verified government funding opportunities

HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)

Open

National Institutes of Health

Deadline: Jan 15, 2027federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to support the development of safe, effective, and non-addictive therapeutics for pain management as part of the NIH HEAL Initiative, focusing on drug discovery and initial translational efforts. Eligible applicants include various government entities, for-profit and small businesses, educational institutions, and nonprofits, among others, with specific exclusions for non-domestic entities. Application details are not provided in the description, but interested parties can contact NIH Grants Information for further inquiries.

Full Description

This funding opportunity is part of a suite of NOFOs within the NIH HEAL Initiative to support the development of safe, effective, and non-addictive therapeutics to treat pain. The goal is to encourage initial translational efforts that will support a drug discovery program and advance projects to the point where they meet the entry criteria for the Pain Therapeutics Development Program. The scope will therefore be focused on development of assays to support a distinct testing funnel, screening efforts to identify hits, and initial characterization of hits and potential therapeutic agents (including small molecules, biologics, and natural products).

Eligibility

Eligible applicants

Government

  • City or township governments
  • Public and Indian housing authorities
  • State governments
  • Special district governments
  • Federally recognized Native American tribal governments
  • County governments

Business

  • For-profit organizations other than small businesses
  • Small businesses

Education

  • Public and state institutions of higher education
  • Independent school districts
  • Private institutions of higher education

Miscellaneous

  • Other

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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