Funding Opportunity Announcement for Impact of Environmental Exposures on Gut-Brain Signaling in Neurological Conditions (R01)
OpenUpdated: Oct 30, 2025
Summary
The National Institute of Environmental Health Sciences (NIEHS) is preparing to publish a Notice of Funding Opportunity (NOFO) aimed at advancing research on the gut microbiome-brain axis to enhance detection, prevention, and intervention strategies for neurological diseases linked to environmental exposures. Eligible applicants include government entities, for-profit and small businesses, nonprofits, and educational institutions. While applications are not currently being accepted, potential applicants are encouraged to start developing collaborations and project ideas in anticipation of the upcoming NOFO.
Full Description
Description
The National Institute of Environmental Health Sciences (NIEHS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research that builds on our understanding of the gut microbiome-brain axis for the purpose of identifying improved detection, prevention, and intervention strategies for environmental exposure-induced neurological diseases. Given the overlapping gut-brain signaling pathways and the prevalence of neurological conditions with gut-related comorbidities, the scope of this program would be inclusive of a wide range of neurological outcomes, including mental health disorders and chronic neurodegenerative conditions such as Parkinson’s disease and Alzheimer’s disease. The objective of this program is to develop gut-focused intervention strategies (e.g., probiotics, microbial biomarkers, nutritional supplements and novel therapeutics) to decrease risk, slow progression, or possibly reverse these neurological condition(s). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise and insights into this area of biological mechanisms underlying the effects of environmental exposures on neurological outcomes and the mediating role of the gut-brain axis are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in toxicology, microbiome, and neuroscience will be encouraged and these investigators should also begin considering applying for this application.
Eligibility
Eligible applicants
Government
- County governments
- Public and Indian housing authorities
- Federally recognized Native American tribal governments
- State governments
Business
- For-profit organizations other than small businesses
- Small businesses
Nonprofit
- Other Native American tribal organizations
- Nonprofits non-higher education with 501(c)(3)
Education
- Independent school districts
- Public and state institutions of higher education
- Private institutions of higher education
Miscellaneous
- Other
Additional information
Grantor contact information
Description
anika.dzierlenga@nih.gov
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