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Engineering Next-Generation Human Nervous System Microphysiological Systems (R21 Clinical Trials Not Allowed)

Open

National Institutes of Health

Deadline: Jan 7, 2026federal

Updated: Oct 30, 2025

Summary

The grant aims to support research applications focused on developing advanced human cell-derived microphysiological systems (MPS) that accurately replicate complex nervous system structures and functions, facilitating studies on nervous system development and aging in various health conditions. Eligible applicants include small businesses, various nonprofit organizations, state and local governments, educational institutions, and other specified entities. Application details are not provided in the description; for further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.

Full Description

Description

This Notice of Funding Opportunity (NOFO) encourages research grant applications directed toward developing next-generation human cell-derived microphysiological systems (MPS) and related assays that replicate complex nervous system architectures and physiology with improved fidelity over current capabilities. Supported projects will be expected to enable future studies of complex nervous system development, function and aging in healthy and disease states.

Eligibility

Eligible applicants

Business

  • Small businesses
  • For-profit organizations other than small businesses

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)
  • Nonprofits non-higher education without 501(c)(3)

Government

  • State governments
  • Federally recognized Native American tribal governments
  • City or township governments
  • Special district governments
  • Public and Indian housing authorities
  • County governments

Education

  • Independent school districts
  • Private institutions of higher education
  • Public and state institutions of higher education

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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