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Engineering Next-Generation Human Nervous System Microphysiological Systems (R01 Clinical Trials Not Allowed)

Open

National Institutes of Health

Deadline: Jan 7, 2026federal

Updated: Oct 30, 2025

Summary

The grant aims to support research in developing next-generation human cell-derived microphysiological systems (MPS) that accurately replicate complex nervous system architectures and physiology, facilitating studies on nervous system development, function, and aging. Eligible applicants include independent school districts, public and private higher education institutions, various levels of government, for-profit and small businesses, nonprofits, and other organizations such as tribal governments and historically Black colleges. Application details are not specified in the provided text; interested parties should refer to the full opportunity announcement for more information.

Full Description

Description

This Notice of Funding Opportunity (NOFO) encourages research grant applications directed toward developing next-generation human cell-derived microphysiological systems (MPS) and related assays that replicate complex nervous system architectures and physiology with improved fidelity over current capabilities. Supported projects will be expected to enable future studies of complex nervous system development, function and aging in healthy and disease states.

Eligibility

Eligible applicants

Education

  • Independent school districts
  • Public and state institutions of higher education
  • Private institutions of higher education

Government

  • State governments
  • City or township governments
  • County governments
  • Public and Indian housing authorities
  • Federally recognized Native American tribal governments
  • Special district governments

Business

  • For-profit organizations other than small businesses
  • Small businesses

Miscellaneous

  • Other

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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