Engineering Improved Stem Cell-Derived Islet Cells for Replacement Therapies
OpenUpdated: Oct 30, 2025
Summary
The National Institute of Diabetes and Digestive and Kidney Diseases is offering a funding opportunity to support research aimed at engineering characteristics of stem cell-derived islet cell products to enhance cell replacement therapy outcomes. Eligible applicants include various organizations such as nonprofits, educational institutions, for-profit businesses, and government entities. While applications are not currently being solicited, potential applicants are encouraged to prepare collaborative projects and consider applying once the NOFO is officially published.
Full Description
Description
The National Institute of Diabetes and Digestive and Kidney Diseases intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on understanding how to engineer inherent characteristics of stem cell-derived islet cell products that can result in improved cell replacement therapy outcomes. Unlike cadaveric human islets, stem cell-derived islet cell products are generated from well-defined and highly controlled cell bank sources. Their banking, manufacturing, and quality control processes can be used to instill optimized cell characteristics resulting in more resilient and durable graft viability and function. This funding opportunity will aim to stimulate studies on targets and pathways amenable to such engineering approaches and to encourage preclinical testing and validation of such strategies. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise and insights into this area of stem cell-derived islet cell replacement therapies are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in stem cell and islet biology, transplant immunology, and type 1 diabetes autoimmunity and preclinical models will be encouraged and these investigators should also begin considering applying for this application.
Eligibility
Eligible applicants
Miscellaneous
- Other
Nonprofit
- Nonprofits non-higher education without 501(c)(3)
- Nonprofits non-higher education with 501(c)(3)
- Other Native American tribal organizations
Education
- Private institutions of higher education
- Public and state institutions of higher education
- Independent school districts
Business
- For-profit organizations other than small businesses
- Small businesses
Government
- State governments
- City or township governments
- Federally recognized Native American tribal governments
- Public and Indian housing authorities
- County governments
Additional information
Grantor contact information
Description
albert.hwa@nih.gov
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