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Elucidating Immunometabolic Responses to HIV Infection that Increase TB or HBV Risk (R01 Clinical Trial Not Allowed)

Open

National Institutes of Health

Deadline: Jan 7, 2028federal

Updated: Oct 30, 2025

Summary

The grant aims to support research on how HIV-induced immunometabolic changes in individuals on combination antiretroviral therapy affect immune responses and increase the risk of poor outcomes from secondary infections like Mycobacterium tuberculosis and hepatitis B virus. Eligible applicants include various government entities, nonprofits, educational institutions, small businesses, and other organizations, including those serving specific communities and demographics. Application details are not provided in the description, but interested parties can contact NIH Grants Information for further inquiries.

Full Description

Description

The purpose of this notice of funding opportunity (NOFO) is to support research to elucidate how HIV-induced immunometabolic alterations, in a host suppressed on combination antiretroviral therapy (cART-suppressed), impact the immune response and increase risk for poor outcomes due to a second, potentially long-term, infection such as Mycobacterium tuberculosis (Mtb) or hepatitis B virus (HBV). This NOFO aims to support research to define how HIV-driven alterations to immunometabolism affect immune cell regulation, cell-cell interactions, response to treatment, and, ultimately, tuberculosis (TB) and HBV disease progression.

Eligibility

Eligible applicants

Government

  • County governments
  • Federally recognized Native American tribal governments
  • State governments
  • Public and Indian housing authorities
  • Special district governments
  • City or township governments

Miscellaneous

  • Other

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)

Education

  • Private institutions of higher education
  • Public and state institutions of higher education
  • Independent school districts

Business

  • Small businesses
  • For-profit organizations other than small businesses

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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