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Effectiveness Trials to Test Mental Health System Interventions (R61/R33 Clinical Trial Required)

Open

National Institutes of Health

Deadline: Oct 15, 2027federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to support the feasibility and infrastructure development of mental health service interventions, followed by well-powered clinical trials to test their effectiveness in improving care processes and outcomes. Eligible applicants include various nonprofit organizations, educational institutions, government entities, and for-profit organizations, including small businesses. Application details are not specified in the provided text, but interested parties can contact NIH Grants Information for further inquiries.

Full Description

Description

This R61/R33 concept complements NIMHs suite of clinical trial NOFOs by supporting feasibility and infrastructure development (R61) followed by well-powered clinical trials (R33) to test the effectiveness of system interventions and strategies for improving the organization, delivery, coordination, and clinical and functional outcomes of mental health services. System interventions - which may span, for example, structural, policy, organizational, and interpersonal domains - attend to issues about the access, equity, engagement/utilization, value (cost/financing), management, or quality and safety...

Eligibility

Eligible applicants

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations

Education

  • Independent school districts
  • Public and state institutions of higher education
  • Private institutions of higher education

Government

  • Special district governments
  • County governments
  • Federally recognized Native American tribal governments
  • State governments
  • City or township governments
  • Public and Indian housing authorities

Miscellaneous

  • Other

Business

  • For-profit organizations other than small businesses
  • Small businesses

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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