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Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R01 Clinical Trial Optional)

Open

National Institutes of Health

Deadline: May 7, 2026federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to support research applications focused on developing and evaluating novel radioligands for PET or SPECT imaging in the human brain, including pilot or clinical feasibility evaluations based on pre-clinical data. Eligible applicants include various government entities, nonprofit organizations, educational institutions, small businesses, and other specified organizations, including those serving Native American populations. To apply, interested parties should refer to the full opportunity announcement for detailed instructions and contact NIH Grants Information for further inquiries.

Full Description

Description

This Notice of Funding Opportunity (NOFO) invites research grant applications that propose the development and evaluation of novel radioligands for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging in human brain and the incorporation of, pilot or clinical feasibility evaluation from previously collected data in pre-clinical studies. These studies are expected to provide the requisite data needed to advance promising PET ligands for use in clinical research.

Eligibility

Eligible applicants

Government

  • County governments
  • City or township governments
  • Special district governments
  • State governments
  • Public and Indian housing authorities
  • Federally recognized Native American tribal governments

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations

Education

  • Independent school districts
  • Private institutions of higher education
  • Public and state institutions of higher education

Business

  • Small businesses
  • For-profit organizations other than small businesses

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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