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Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)

Open

National Institutes of Health

Deadline: Jan 7, 2027federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to support R21 applications focused on developing novel theories and methods to understand the contributions of genetic and non-genetic factors to complex trait variation across individuals, families, and populations, utilizing interdisciplinary approaches and large-scale datasets. Eligible applicants include various nonprofit organizations, for-profit businesses, government entities, educational institutions, and other specified organizations such as tribal governments and minority-serving institutions. Application details are not provided in the description; interested parties should refer to the full opportunity announcement for more information.

Full Description

Description

The goal of this NOFO is to support R21 applications for novel theory and methods development that better delineate how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary across the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, simulations, and validation using available large-scale datasets

Eligibility

Eligible applicants

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)

Business

  • For-profit organizations other than small businesses
  • Small businesses

Miscellaneous

  • Other

Government

  • State governments
  • Federally recognized Native American tribal governments
  • City or township governments
  • County governments
  • Public and Indian housing authorities
  • Special district governments

Education

  • Independent school districts
  • Private institutions of higher education
  • Public and state institutions of higher education

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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