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Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)

Open

National Institutes of Health

Deadline: Nov 5, 2026federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to support the development of novel theories and methods that enhance the understanding of genetic and non-genetic factors influencing complex trait variation across individuals, families, and populations, utilizing interdisciplinary approaches and large-scale datasets. Eligible applicants include various nonprofit organizations, government entities, educational institutions, and for-profit organizations, including small businesses. To apply, interested parties should refer to the full opportunity announcement for detailed application instructions and contact NIH Grants Information for further inquiries.

Full Description

The goal of this NOFO is to support applications for novel theory and methods development that enable better understanding of how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary drawing from the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, modeling, and validation with available large-scale datasets.

Eligibility

Eligible applicants

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)

Government

  • Federally recognized Native American tribal governments
  • Special district governments
  • City or township governments
  • County governments
  • State governments
  • Public and Indian housing authorities

Miscellaneous

  • Other

Education

  • Public and state institutions of higher education
  • Private institutions of higher education
  • Independent school districts

Business

  • For-profit organizations other than small businesses
  • Small businesses

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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