Collaborative Opportunities for Multiple-disciplinary, Bold, and Innovative Neuroscience (COMBINE) (RM1 Clinical Trial Optional)
OpenUpdated: Oct 30, 2025
Summary
The National Institute of Neurological Disorders and Stroke (NINDS) is planning to publish a Notice of Funding Opportunity (NOFO) to support transdisciplinary team science aimed at overcoming barriers in neuroscience and advancing the NINDS mission within five years. Eligible applicants include government entities, nonprofits, educational institutions, and for-profit organizations, among others. While applications are not currently being solicited, interested parties are encouraged to begin forming collaborations and developing projects in anticipation of the NOFO release; inquiries can be directed to NINDSteamscience@nih.gov.
Full Description
Description
The National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications from highly-integrated transdisciplinary team science led by 3-6 PDs/PIs to pursue a single focused goal to overcome persistent barriers, challenge orthodoxies, achieve paradigm-shifts, or develop new foundational principles in neuroscience. Within five-years, the team must deliver outcomes significantly advancing the NINDS mission and transform knowledge and practice, ranging from fundamental neuroscience to human health. The research question(s) should be of sufficient scope and complexity to necessitate an innovative convergence of disciplines, expertise, and coordination, beyond the scope of traditional R01 or Program Project/Center grant mechanisms. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of neuroscience and neurology are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations from newly formed or established teams, combining expertise in various fields of basic, clinical, and translational domains of neuroscience will be encouraged, and these investigators should also begin considering applying for this application.
Eligibility
Eligible applicants
Government
- City or township governments
- State governments
- Special district governments
- Federally recognized Native American tribal governments
- Public and Indian housing authorities
- County governments
Miscellaneous
- Other
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Nonprofits non-higher education without 501(c)(3)
- Other Native American tribal organizations
Education
- Private institutions of higher education
- Independent school districts
- Public and state institutions of higher education
Business
- For-profit organizations other than small businesses
- Small businesses
Additional information
Grantor contact information
Description
NINDSteamscience@nih.gov
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