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Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed)

Open

National Institutes of Health

Deadline: Nov 18, 2027federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to support research aimed at understanding and mitigating the harmful effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids and their combinations, as well as investigating the long-term pathophysiological effects following such exposure. Eligible applicants include various government entities, educational institutions, small and for-profit businesses, and nonprofits, among others. To apply, interested parties should refer to the full opportunity announcement for specific application details and requirements.

Full Description

This notice of funding opportunity (NOFO) will support research towards understanding and mitigating the deleterious effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids (e.g., fentanyl, carfentanil, nitazenes) and their combinations (fentanyl and xylazine). This NOFO will also support research on the persistent and/or delayed pathophysiological effects after acute exposure to such agents.

Eligibility

Eligible applicants

Government

  • City or township governments
  • Public and Indian housing authorities
  • Special district governments
  • County governments
  • Federally recognized Native American tribal governments
  • State governments

Education

  • Independent school districts
  • Public and state institutions of higher education
  • Private institutions of higher education

Business

  • Small businesses
  • For-profit organizations other than small businesses

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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