The NIH Common Fund, National Institute on Aging, National Cancer Institute and additional NIH Institutes and Centers (ICs) intend to publish a Notice of Funding Opportunity (NOFO) to solicit applications for Stage 2 of the Cellular Senescence Network (SenNet) Program, which seeks to understand the biological consequences of senescent cell heterogeneity in health and disease, identify and characterize tissue-specific senescence markers in human biospecimens to facilitate the development of senotherapeutic strategies that improve health outcomes. The program’s Senescence Technology Projects (SenTecs) will develop innovative tools and technologies that consider the complex nature of senescence to facilitate identification, characterization and targeting of senotypes in vivo. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into the cellular senescence impact on human health, the development of technologies and computational tools to identify and characterize senescent cells and inform novel approaches for the strategic targeting of senescent cells in vivo are encouraged to apply in response to these new NOFOs.

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