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Catalyze: Product Definition for Small Molecules, Biologics and Combination Products - Target Identification and Validation, and Preliminary Product/Lead Series Identification (R61/R33 Clinical Trials Not Allowed)

Open

National Institutes of Health

Deadline: Dec 23, 2027federal

Updated: Oct 30, 2025

Summary

The NHLBI Catalyze Program aims to support the transition of basic science discoveries into viable diagnostic and therapeutic candidates for human testing, specifically through the Catalyze Product Definition initiative focused on identifying potential therapeutic candidates for HLBS diseases. Eligible applicants include various government entities, nonprofits, educational institutions, and for-profit organizations, including small businesses. Application details are not specified in the provided text, but interested parties can contact NIH Grants Information for further inquiries.

Full Description

The goal of the NHLBI Catalyze Program is to provide a comprehensive suite of support and services to facilitate the transition of basic science discoveries into viable diagnostic and therapeutic candidates that have been cleared for human testing, and to develop translational researchers fluent in product development and entrepreneurship. This specific Catalyze Product Definition initiative will provide the early stage translational support needed for the activities required to identify and characterize potential therapeutic candidates and combination products to treat HLBS diseases and disorders....

Eligibility

Eligible applicants

Government

  • County governments
  • City or township governments
  • Public and Indian housing authorities
  • Special district governments
  • State governments
  • Federally recognized Native American tribal governments

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)

Miscellaneous

  • Other

Education

  • Independent school districts
  • Public and state institutions of higher education
  • Private institutions of higher education

Business

  • For-profit organizations other than small businesses
  • Small businesses

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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