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Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)

Open

National Institutes of Health

Deadline: Aug 18, 2027federal

Updated: Oct 30, 2025

Summary

The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) grant supports the discovery and development of biologic-based therapeutics, covering preclinical stages through phase I clinical testing. Eligible applicants include various government entities, educational institutions, nonprofits, and businesses, including small and for-profit organizations. To apply, interested parties should refer to the full opportunity announcement for specific application details and contact NIH Grants Information for further inquiries.

Full Description

The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic discovery and development, from lead optimization through phase I clinical testing. This Funding Opportunity Announcement (FOA) supports preclinical discovery and development of potential therapeutic Biotechnology Products and Biologics including, but not limited to, large biologic macromolecules, (e.g., proteins, antibodies, and peptides), gene-based therapies (i.e., oligonucleotide- and viral-based), cell therapies, and novel emerging therapies (e.g., microbial and microbiome therapies)....

Eligibility

Eligible applicants

Government

  • Special district governments
  • County governments
  • Public and Indian housing authorities
  • City or township governments
  • State governments
  • Federally recognized Native American tribal governments

Education

  • Public and state institutions of higher education
  • Private institutions of higher education
  • Independent school districts

Miscellaneous

  • Other

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)

Business

  • Small businesses
  • For-profit organizations other than small businesses

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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