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Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

Open

National Institutes of Health

Deadline: Aug 18, 2027federal

Updated: Oct 30, 2025

Summary

The grant aims to support the discovery and development of biologic-based therapeutics, including large macromolecules, gene-based therapies, and cell therapies, from lead optimization through phase I clinical testing. Eligible applicants include small businesses, while non-domestic entities and non-domestic components of U.S. organizations are not eligible to apply. For application details, refer to the full opportunity announcement, and inquiries can be directed to NIH Grants Information at grantsinfo@nih.gov.

Full Description

Reissue PAR-21-233 - The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic discovery and development, from lead optimization through phase I clinical testing. This Funding Opportunity Announcement (FOA) supports preclinical discovery and development of potential therapeutic Biotechnology Products and Biologics including, but not limited to, large biologic macromolecules, (e.g., proteins, antibodies, and peptides), gene-based therapies (i.e., oligonucleotide- and viral-based), cell therapies, and novel emerging therapies (e.g., microbial...

Eligibility

Eligible applicants

Business

  • Small businesses

Additional information

Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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