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Awards Supporting Cutting-Edge Technologies for Translational Science (ASCETTS) (R21 Clinical Trials Not Allowed)

Open

National Institutes of Health

Deadline: Jun 18, 2026federal

Updated: Oct 30, 2025

Summary

The grant aims to support the development of innovative technologies that address challenges in translational science, particularly in therapeutic development, by funding early-stage, high-risk studies that can enhance the efficiency of the therapeutic development pipeline. Eligible applicants include public and private educational institutions, government entities, for-profit and nonprofit organizations, and various other groups, including tribal organizations and historically underrepresented institutions. Application details are not specified in the provided text, but interested parties can contact NIH Grants Information for further inquiries.

Full Description

Description

The National Center for Advancing Translational Sciences (NCATS) invites applications for the Awards Supporting Cutting-Edge Technologies for Translational Science (ASCETTS) Notice of Funding Opportunity (NOFO) to foster investigator-initiated development of highly innovative technologies to address barriers, limitations, or bottlenecks in translational science particularly for therapeutic development. This program will support the early-stage proof of concept, high-risk and potentially high-reward studies for feasibility and exploratory technology development, which can transform or significantly improve the efficiency of therapeutic development to achieve NCATS ultimate goals - more treatments to all people more quickly. The research proposed should be for the development of technology that can break new ground or extend present technology toward new directions or novel applications. With this initiative, we expect to support the development and/or prototyping of new technologies that will lead to improved efficiency in the therapeutic development pipeline.

Eligibility

Eligible applicants

Education

  • Public and state institutions of higher education
  • Independent school districts
  • Private institutions of higher education

Government

  • City or township governments
  • State governments
  • Federally recognized Native American tribal governments
  • Special district governments
  • Public and Indian housing authorities
  • County governments

Miscellaneous

  • Other

Business

  • For-profit organizations other than small businesses
  • Small businesses

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)
  • Nonprofits non-higher education without 501(c)(3)

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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