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Assay Development and Screening for Discovery of Validated Chemical Hits for Brain Disorders (R01 Clinical Trial Not Allowed)

Open

National Institutes of Health

Deadline: May 7, 2026federal

Updated: Oct 30, 2025

Summary

The purpose of this grant is to stimulate research in the discovery and development of novel small molecules for potential use in treating psychiatric disorders and to gain new insights into the biology of relevant diseases. Eligible applicants include government entities, nonprofits, businesses, educational institutions, and various other organizations, including those serving specific communities such as Native American and Hispanic-serving institutions. To apply, interested parties should refer to the full opportunity announcement for detailed instructions and contact NIH Grants Information for further inquiries.

Full Description

The objective of this Notice of Funding Opportunity (NOFO) is to stimulate research in 1) discovery and development of novel, small molecules for their potential use in studying disease treatment relevant to psychiatric disorders; and 2) to generate new insight into the biology of relevant diseases and processes that have yet to be validated as important drug targets.

Eligibility

Eligible applicants

Government

  • Special district governments
  • State governments
  • County governments
  • Federally recognized Native American tribal governments
  • Public and Indian housing authorities
  • City or township governments

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)

Business

  • Small businesses
  • For-profit organizations other than small businesses

Education

  • Independent school districts
  • Public and state institutions of higher education
  • Private institutions of higher education

Miscellaneous

  • Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Apply on official siteUpdated Oct 30, 2025

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